《南方醫(yi)科大學學報(bao)》雜志上，來自湖北民(min)族學院(yuan)研究(jiu)人(ren)員發表論文(wen)，旨在探討蒼術(shu)提取(qu)物(Rhizome Atractylodes extract，ERA)保(bao)護(hu)胃(wei)粘膜的(de)作用及對脾虛(xu)模型大鼠胃(wei)腸免疫功能的(de)影響，闡(chan)明ERA干(gan)預脾虛(xu)證的(de)作用機制。

研究指出，ERA可抑制脾虛證大鼠胃粘(zhan)膜損(sun)(sun)害，保護(hu)和修(xiu)復損(sun)(sun)傷的(de)粘(zhan)膜組織，并改善脾虛證大鼠的(de)免疫功能。

采用喂飼小承氣湯煎劑加饑飽失常建立大鼠脾虛證模型，（Shaanxi Pioneer Biotech Co., Ltd.）模型復制成功后動物隨機分為脾虛模型組，ERA高、中、低劑量組，多潘立酮組。連續灌胃給藥10 d。采用腸道灌流法檢測大鼠腸道灌流液Ig A含量，腹主動脈采血法檢測大鼠血清Ig G含量，并測定大鼠胸腺、脾臟指數，（陜西帕尼爾生物科(ke)技(ji)有限公司）HE染色行大鼠胃黏膜病理學觀察，激光多普勒微循環血流計行大鼠胃黏膜血流量的測定，免疫組化法測定大鼠胃黏膜組織中TFF1及結腸TLR4的表達量。

與正常組(zu)(zu)比較，模(mo)(mo)型組(zu)(zu)大鼠(shu)胃黏膜形(xing)態(tai)(tai)學(xue)、胃黏膜血流(liu)量(liang)、相關免疫學(xue)指(zhi)標顯著改(gai)變(bian)；與模(mo)(mo)型組(zu)(zu)比較，ERA各劑量(liang)組(zu)(zu)大鼠(shu)胃黏膜形(xing)態(tai)(tai)學(xue)、胃黏膜血流(liu)量(liang)、胃黏膜組(zu)(zu)織中三葉因子1(TFF1)的表達量(liang)，腸(chang)道灌流(liu)液Ig A、血清Ig G含量(liang)、胸(xiong)腺、脾(pi)臟指(zhi)數及結腸(chang)TLR4的表達量(liang)不同程度升高(gao)，差異均有統計(ji)學(xue)意義(P<0.05或P<0.01)。

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